A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

• Guido Gambacorta,
• James S. Sharley and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

• reactor is, in certain instances, indicated to give rise to superior reaction kinetics [79]. It is also easy to create staged temperature gradients to compensate for changes in reaction kinetics based upon concentration or complicating effects such as product derived auto-catalysis. The use of immobilised

• reagents has also greatly aided in the development of impressive sequential multistep sequences in flow by acting as direct in-line quenching, work-up and purification steps [28][80][81][82][83][84][85]. Indeed, the scavenger approach to removing excess solution phase reagents or byproducts has had a

The rapid generation of isothiocyanates in flow

• Marcus Baumann and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2013, 9, 1613–1619, doi:10.3762/bjoc.9.184

• are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the

• chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream. Keywords: chloroxime; dipolar cycloaddition; flow chemistry; flow synthesis; immobilised reagents; isothiocyanate; nitrile oxide; Introduction Flow based chemical

• still seen and there normally remains the requirement for time consuming purifications such as column chromatography in order to isolate pure products. Immobilised reagents have shown great promise as enabling technologies when incorporated in flow reactors to aid in the processing, work-up and

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

• Kimberley A. Roper,
• Heiko Lange,
• Anastasios Polyzos,
• Malcolm B. Berry,
• Ian R. Baxendale and
• Steven V. Ley

Beilstein J. Org. Chem. 2011, 7, 1648–1655, doi:10.3762/bjoc.7.194

• rate of reaction observed as well as to circumvent problems associated with the use of bead-based immobilised reagents in continuous flow. Results and Discussion Formation of the triphenylphosphine monolith The triphenylphosphine monoliths were formed by precipitation polymerisation of the appropriate

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

• Alessandro Palmieri,
• Steven V. Ley,
• Anastasios Polyzos,
• Mark Ladlow and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23

• , Melbourne, Australia, 3169 Uniqsis, Shepreth, Cambridgeshire, SG8 6GB, United Kingdom 10.3762/bjoc.5.23 Abstract Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of α-ketoesters is reported. Keywords: catch

• Uniqsis FlowSyn™ unit to achieve multi-step organic synthesis under continuous flow-chemistry conditions. This was accomplished by adapting the device to incorporate immobilised reagents packed in flow tubes, enabling clean transformations without recourse to conventional product work-up or purification